Monday, September 22, 2008

New Help for Connective Tissue Disorders

Did you know that there are 200 disorders tied into the umbrella of Connective Tissue Disorders? New advances in nutrition-specific proteomics and nutrigenomics now provides a new and incredibly effective protocol for care of many of these various disorders, which is a long list. Other than the primary genetic disorders such as the Ehlers-Danlos Hypermobility, Marfans, and Osteogenesis Imperfectus, the following disorders have been included also:

· Scoliosis
· Sunken chest (pectus excavatum)
· Barrel chest (pectus carinatum)
· Fibromyalgia
· Double jointedness (hypermobility)
· Migraines
· Mitral Valve Prolapse
· Back pain
· Muscle twitches and ticks
· Vertigo
· Easy bruising
· Neck pain
· Kyphosis (rounded shoulders)
· Frozen shoulders
· Sciatica
· Itching/sensitive skin
· Muscle cramps, especially in the calves
· Obsessive compulsive disorder
· Tinnitus
· Scarring
· Cellulitis as a result of infection
· Plantar Fascitis
· Rheumatoid arthritis
· Systemic Lupus
· And lots of others…

Significant scientific breakthroughs in nutritional medicine provide hope for many of these disorders.

At the Functional Medicine Research Center, a study on patients who previously did not respond to multiple manual adjustments given a formula containing berberine, folic acid, tetra iso-alpha acids from hops, niacinamide, and selenium had 70% pain management within 24 hours and sustained at 47% pain management at 7 days (average)!

This formula works by down-regulating an enzyme pathway called, MMP, which is a collagen degradation mechanism. It would be especially appropriate for tendonopathy, repetitive injury, hypermobile joints, and soft tissue injuries. For chiropractic physicians and osteopaths who perform manual manipulations, it would be appropriate for all patients who do not hold their adjustments.

Mechanism of Action
Matrix Metalloproteinase (MMP) are collagen-digesting enzymes naturally produced by chondrocytes after injury. They serve, in part, to remodel new connective tissue just like osteoclasts remodel new bone tissue. However, poor diet, lifestyle, repetitive injuries can trigger cell signals which can lead to over-activated release of MMPs. Excessive release of MMPs can damage and degrade healthy tendons and cartilage tissue.

The new extra-cellular matrix-supporting product called has specific natural compounds shown in studies to regulate specific MMP enzymes. For example, tetra iso-alpha acids from hops modulate MMP-13. Selenium addresses MMP-1 and MMP-2. Folic acid impacts homocysteine to positively influence MMP-9, and niacinamide down-regulates the tissue-damaging PARS cycle. Berberine, known best for its anti-pathogen power, is also an effective ingredient which can prevent skin inflammation and the degredation of extracellular matrix proteins.

Results of Research
In a multi-site evaluation of 12 “difficult” patients where previous bodywork was only mildly helpful, the nutritional formula was given for 7 days. The patients’ average initial pain score on a 1-10 scale (10 being the worst) was 7, and the average initial flexibility score was 3 (1 being the worst in terms of stiffness). Pain scores over the course of seven days were “dramatically” decreased (range: 2-4) relative to the baseline median score of 7. Flexibility scores also improved.

A case study provided by Dr. John Hallawell, DC, showed that significant improvement in range of motion and trigger point sensitivity allowed the application of deeper manipulation compared to prior to the administration of the product.

A Testimonial
I prefer to stick to research rather than testimonials, but once in a while a testimony is helpful when combined with the research.

Mara from Michigan has the connective tissue disorder, Ehlers-Danlos, the hypermobility type. As she describes it, “the tendons and ligaments don’t form well and become like old rubber bands and do not have the elasticity that is the norm. So anything inflammatory will make it a lot worse and I start dislocating. However, thanks to lifestyle changes and Metagenics, I got out of most of the braces, gave up the inflammatory foods and comparatively speaking was doing lots better. But the connective tissue pain has still been hounding me and I have never been able to exercise since any repetitive motion would end up dislocating me. I received the [nutritional formula] on a Friday afternoon. I took two right then and two before bed, two the next morning. By noon on Saturday almost all the pain in my elbow was gone! Within 4 days it didn’t even hurt to the touch anymore and within three weeks, my chiro was able to adjust my back, my shoulders finally released, and I am pain free for the first time in a year! I can’t even tell you how wonderful that is! I did go off for a couple days and the pain started coming back. The great thing is now that I have a loading dose in me, it will work within half an hour now.”

This new formula is another in the growing family of unique Selective Kinase Response Modulators (SKRMs) created with the proteomic method. Proteomics is the science of how certain substances effect physiology and pathophysiology. This method allows researchers to remove the guesswork associated with much of the extrapolation of the research associated with nutritional compounds and allows them to evaluate exactly how certain combinations of nutrients are going to effect physiology and pathophysiology. Thus, a new era has emerged that may provide new hope for those suffering from chronic connective tissue disorders.